OUR APPROACH & TECHNOLOGY
Single-Cell Response
Unraveling the complexity of biology through technology
QuRIE-seq was designed to address the gap on the market to unlock the black box biology, empowering drug developers to better understand cellular responses and ultimately develop more effective therapies for patients. QuRIE-seq builds on world-leading expertise in microfluidics, single-cell analysis, molecular biology, reaction network biochemistry, and bioinformatics. This powerful combination enables us to “lock” biology—freezing specific cell signaling states—and, for the first time, generate high-throughput timelapse maps of cellular responses at single-cell resolution.
QURIEGEN PLATOFORM
The most in-depth insights into cellular responses
Our
Approach
QuRIE-seq is developed entirely in-house, giving us the flexibility to continually refine and improve the platform. This allows us to seamlessly incorporate additional steps or modify protocols to meet the specific needs of our clients.
QuRIE-seq is a unique, all-in-one platform that provides drug developers and researchers with unprecedented, high-resolution data. You can fully outsource your work to us, and we’ll ensure you receive the precise insights you require.
By generating 10x more insights, we offer a single, integrated solution that saves time and resources in the long run, empowering you to make more informed decisions throughout the drug development process.
Core
Technology
“Single-cell” refers to the ability to analyze individual cells as unique entities, like molecular detectives investigating each cell’s distinct characteristics. This approach offers exceptional molecular resolution and uncovers previously hidden biological insights (biochemical heterogeneity, distinctions between “high responders” and “low responders,” which have direct implications for patient stratification and treatment outcomes).
“Multi-omic” refers to the simultaneous integration of multiple molecular layers, such as transcriptomics and proteomics. It’s like building a detailed “Google Maps” of the cell, where each molecular layer represents a different form of transportation: transcriptomics as highways, proteomics as railways, and phosphoproteomics as tram lines, providing a comprehensive view of cellular responses. These layers are essential for understanding not only disease mechanisms and drug interactions, but also their short-term (phosphoproteome), mid-term (transcriptome), and long-term (proteome) effects. Moreover, these conventional approaches struggle to capture cellular response heterogeneity, missing key.
Our proprietary QuRIE-seq technology seamlessly integrates these layers in a high-throughput workflow, allowing for the analysis of thousands of individual cells in a single run.
Applications
By simultaneously analyzing multiple molecular layers within individual cells, we can uncover how genes, transcripts, and proteins interact. This multi-dimensional approach reveals regulatory networks and signaling pathways that drive diseases, enabling the identification of novel biomarkers and targets.
Single-cell multi-omics provides insights into how individual cells respond to drug candidates, shedding light on mechanisms of action, drug resistance, and off-target effects. This helps ensure that only the most effective and least toxic drug candidates move forward to clinical development and provides valuable information on potential reasons for failure or lack of efficacy.
By analyzing patient-derived cells and providing a detailed biochemical profile, we can identify which therapies will be most effective for specific patients. This approach enables the understanding of why a particular treatment will work for one patient and not another, improving treatment precision and outcomes.
QurieGen's approach and technology has been validated by leading pharmaceutical companies
