OUR APPROACH & TECHNOLOGY
Single-Cell Response
Unraveling the complexity of biology through technology
We create a platform that combines proprietary methods of mapping cellular responses, single-cell genomics, and data science to build predictive models of disease biology and drug response to de-risk and accelerate traditional drug discovery and development.
Our QuRIE-seq technology generates unique data that allows for comprehensive, high-throughput analysis of the transcriptome, membrane and intracellular proteome and phosphoproteome at single-cell resolution. This technology characterizes thousands of cells per run, capturing cell response heterogeneity and identifying rare subpopulations missed by bulk experiments, effectively replacing many incompatible analytical tools.
quriegen PLATFORM
The first single-cell platform offering the most in-depth insights into cellular responses
Our
Approach
QuRIE-seq simultaneously quantifies mRNA molecules and hundreds of intracellular proteins and phosphoproteins at single-cell resolution.
Only technology capable of providing a comprehensive view of cellular responses to drug molecules; essential for identifying new drug targets, selecting the most promising candidates, and optimizing treatments.
Reveals off-target effects, toxicity, and resistance mechanisms, de-risking drug development by improving candidate selection, optimizing therapies, and reducing preclinical time and cost.
Our
Technology
Proprietary single-cell, multi-omic platform called QuRIE-seq to map the cellular responses across multiple signaling pathways . QuRIE-seq enables the precise quantification of mRNA molecules and hundreds of membrane and intracellular (phospho)proteins.
QuRIE-seq replaces many incompatible analytical tools that provide only partial views of cellular responses. By decoding cellular responses, it provides valuable insights into how the whole cell reacts to various stimuli or inhibitors, enhancing our understanding of disease and resistance mechanisms, and drug efficacy.
QuRIE-seq leverages droplet microfluidics, molecular biology, complex biochemistry, state-of-the-art single-cell sequencing, and advanced data intelligence.
Applications
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Mechanism of Disease & Biomarker Discovery
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Target Identification & Validation
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Mechanism of Action & Drug Response
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Lead Identification & Optimization
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Pre-clinical Trials
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Clinical Trials
QurieGen's approach and technology has been validated by leading pharmaceutical companies
